Shirley Henderson (born 24 November 1965) is a Scottish actress. Her film roles include playing Gail in Trainspotting (1996), Jude in the three Bridget Jones films (2001/04/16), and Moaning Myrtle in Harry Potter and the Chamber of Secrets (2002) and Harry Potter and the Goblet of Fire (2005). Her other films include Topsy-Turvy (1999), Wilbur Wants to Kill Himself (2002), Frozen (2005), Miss Pettigrew Lives for a Day (2008), Anna Karenina (2012), and the Netflix film Okja (2017).

Henderson starred opposite Robert Carlyle in the BBC series Hamish Macbeth (1995–97), and was nominated for the BAFTA TV Award for Best Supporting Actress for the Channel 4 miniseries Southcliffe (2013). She also played Frances Drummond in the BBC drama Happy Valley (2016). In 2017, she was nominated for the Canadian Screen Award for Best Actress because of her performance in Never Steady, Never Still. For her role as Elizabeth in the original production of Girl from the North Country, she won the 2018 Olivier Award for Best Actress in a Musical.