Andrea Kay "Missi" Pyle (born November 16, 1972) is an American actress and singer. She has appeared in several films, including the award-winning films The Artist, Galaxy Quest, DodgeBall: A True Underdog Story, Big Fish, 50 First Dates, Charlie and the Chocolate Factory, Harold & Kumar Escape from Guantanamo Bay and Gone Girl.

She has also appeared in various television roles, on shows such as Mad About You, Friends, Heroes, Two and a Half Men, Frasier, My Name Is Earl, 2 Broke Girls, Jennifer Falls, and Mom. She is also half of Smith & Pyle, a desert country-rock band, with actress Shawnee Smith, and has appeared in the music video for Foo Fighters' single "Run" as a nurse.