Michael Holmes may refer to:

• Michael Holmes (politician), former leader of the United Kingdom Independence Party
• Michael Holmes (journalist), British television presenter and writer
• Michael Holmes (broadcaster) (born 1960), Australian anchor on CNN
• Michael Holmes (saxophonist) (born 1982), American classical saxophonist
• Michael Holmes (whistleblower) (born 1965), U.S. Army National Guard whistleblower
• Mike Holmes (born 1963), Canadian builder/contractor and TV personality
  • Mike Holmes Jr. , Canadian builder/contractor and TV personality, son of Mike Holmes (Sr.)
• Mike Holmes (wide receiver) (born 1950), played for several teams in the NFL, CFL, and USFL
• Mike Holmes (cornerback) (born 1989), American football cornerback
• Michael W. Holmes, professor of Biblical Studies and Early Christianity, Bethel University
• Micky Holmes (born 1965), English footballer
• Mike Holmes (politician), member of the Alabama House of Representatives